Fig 1: Effect of general anesthesia on membrane expression levels of AMPA receptors in the cerebellum in aged App-KI mice. Mean (+ SEM) protein expression ratio (normalized with the HSP60 expression levels) of GluA1 (A), GluA2 (B), GluA3 (C) and GluA4 (D) subunits in the crude membrane fractions in each group, WT-Air (n = 3), WT-Des (n = 3), WT-Sev (n = 3), App-Air (n = 5), App-Des (n = 5) and App-Sev (n = 5) group, are shown. Individual values were normalized with the mean values of WT-Air group as 1. *p < 0.050; †p < 0.100